منابع مشابه
Leptin receptors
Leptin or obesity receptor (Ob-R) is a member of class I cytokine receptor family. Ob-R, expressed in six isoforms, is the product of alternative RNA splicing of db gene. According to its structural differences, the receptor's isoforms are divided into three classes: long, short, and secretory isoforms. A long, fully active isoform of Ob-Rb is expressed mainly in the hypothalamus, where it take...
متن کاملLeptin and Hypertension in Obesity
Leptin, a peptide discovered more than 10 years ago, decreases food intake and increases sympathetic nerve activity to both thermogenic and non-thermogenic tissue. Leptin was initially believed to be an anti-obesity hormone, owing to its metabolic effects. However, obese individuals, for unknown reasons, become resistant to the satiety and weight-reducing effect of the hormone, but preserve lep...
متن کاملLeptin and leptin receptors during malaria infection in mice.
Leptin, which is involved in a range of physiological processes, could be an important factor in the pathogenesis of malaria. We found that levels of leptin in serum and urine in Plasmodium berghei-infected mice increased progressively after infection, reaching a maximum value on day 6 post-infection. Serum values were approximately five-fold higher in infected mice than in non-infected control...
متن کاملIncreased serum leptin indicates leptin resistance in obesity.
Featured Article: Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292–5. This study was done at a very exciting time in the field of obesity research. Jeffrey Friedman’s group had published the landmark report in December 1994 that described the cloning of the Lep (...
متن کاملRole of Leptin in Obesity
Obesity has been the problem in the societies of developing and developed world. Some diseases caused by obesity. To overcome of those diseases it is necessary to control obesity. Most of the articles showed that the Leptin may be a vital tool to fight against obesity because it is the anti-obesity hormone. By using leptin therapy may be possible to prevent obesity and diseases like hypertensio...
متن کاملLeptin, obesity, and obstructive sleep apnea.
T he United States has the notable distinction of having the highest concentration of obese individuals in the world, with a staggering 55% of the adult population being overweight1–3 The body mass index (BMI; weight in kilograms divided by the square of height in meters) is widely used to distinguish between obese and nonobese adults. Overweight is defined as a BMI measure of 25.0 to 29.9 and ...
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عنوان ژورنال:
gene, cell and tissueجلد ۳، شماره ۴، صفحات ۰-۰
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